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Diazepam is sold under the brand name Valium and alprazolam is sold under the name Xanax. We used a behavioral model of immobility first postulated by Porsolt and Porsolt et al. Mice were forced to swim only once. This may be due to the fact that nifedipine on its own might act as an antidepressant but blocks one imipramine mechanism that depends on L-type calcium channel activation.
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