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Doctors must, of course, take care to avoid adverse interactions with other medications, particularly the two classes of antidepressants, the Selective Serotonin Reuptake Inhibitors SSRIs and Monoamine Oxidase Inhibitors MOIs. Withdrawal symptoms may occur if Ultram is discontinued abruptly. Insomnia and Ultram have a connection, even though Ultram is not a drug that is given to treat insomnia. Ultram is associated with craving and tolerance development.
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